IRAC eMethods
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Acrosternum hilare
Agrypnus variabilis
Aphis citricola
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Aphis gossypii
Aphis pomi
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Frankliniella occidentalis
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Nasonovia ribisnigri
Nephotettix cincticeps
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Psylla spp.
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Tetranychus spp.
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1A & 1B - Acetylcholine esterase inhibitor
2A & 2B - GABA-gated chloride channel antagonists
3A & 3B - Sodium channel modulators
4A & 4B - Nicotinic Acetylcholine receptor agonists
5 - Nicotinic Acetylcholine receptor allosteric activators
6 - Chloride channel activators
7A, 7B, 7C - Juvenile hormone mimics
8A, 8B, 8C & 8D - Miscellaneous nonspecific (multi-site) inhibitors
9B & 9C - Selective homopteran feeding blockers
10A & 10B - Mite growth inhibitors
11 - Microbial disruptors of insect midgut membranes (inc. transgenic crops expressing B.t.)
12A, 12B, 12C, 12D - Inhibitors of mitochondrial ATP synthase
13 - Uncouplers of oxidative phosphorylation via disruption of proton gradient
14 - Nicotinic acetylcholine receptor channel blockers
15 - Inhibitors of chitin biosynthesis, type 0, Lepidopteran
16 - Inhibitors of chitin biosynthesis, type 1, Homopteran
17 - Moulting disruptor, Dipteran
18 - Ecdysone agonists / moulting disruptors
19 - Octopaminergic receptor agonists
20A, 20B & 20C - Mitochondrial complex III electron transport inhibitors (Coupling site II)
21A & 21B Mitochondrial complex I electron transport inhibitors
22A & 22B Voltage-dependent sodium channel blockers
23 - Inhibitors of acetyl CoA carboxylase - Lipid synthesis, growth regulation
24A & 24B - Mitochondrial complex IV electron transport inhibitors
28 - Ryanodine receptor modulators
un - Compounds of unknown or uncertain mode of action (see method description)